Excessive hormone or minerals is never good for your body and can result in cancerous cell growth. In addition, evidence shows that excessive growth hormone increases the risk of developing cancers. Read ahead to know more about increased cancer risks due to HGH.
Increase in the production of hormones by the body cells can enhance the risk of cancer, especially if the growth is faster. The cells grow at a faster rate and then get divided quickly. Human growth hormone (HGH) is the most abundant hormone secreted by the anterior pituitary gland, which is the hormone production center in the brain. Secretion of growth hormone starts in early life and reaches at peaks during puberty.
Synthesis of HCG:
HCG induces a cascade of cellular signaling by binding to cellular receptors. HCG stimulates the bone growth, metabolism of fats, stimulates protein synthesis and opposes the action of insulin. Under secretion of HCG can lead to the growth failure and children with these problems are administered recombinant HCG called somatropin.
There are lots of people who are administered with HCG to fight the aging problem, but the risk of death was reported to be amplified when higher than recommended dose was administered.
Risk of Tumor Occurrence:
However, newer treatment strategies have decreased mortality rates substantially. However, the risk of developing a variety of late complications is directly attributable to their previous cancer treatment.
A brain tumor is a common cause of death among the patient who is treated with GH. As per the experts, the research shows that recurrence rated are greater after this treatment than the untreated patients.
According to information published by Karger Publishers, growth hormone possesses the capacity to stimulate the growth of diverse tissues, a characteristic that extends to tumors. In individuals with a predisposition to specific conditions, the administration of growth hormone may unintentionally expedite the growth of pre-existing tumors. This phenomenon underscores the importance of considering individual health factors.
GH can influence the regulation of cellular growth via its mediator peptide IGF-1. IGF-1 may affect the growth of neoplastic tissue and extensive studies show that there is a link between GH and IGF-1 and cancer risk.
According to research findings from Oxford Academy, both Growth Hormone (GH) and Insulin-like Growth Factor-1 (IGF-1) possess inherent capabilities to stimulate cell division and growth. While these processes are essential for normal development and tissue repair, the concern arises when cell growth becomes excessive or uncontrolled, as it has the potential to contribute to the development of cancer.
Patients who are suffering from acromegaly caused due to under secretion of GH, indicate the risk of colorectal cancer. Experimental pieces of evidence show that GH/IGF-1 provides an antiapoptotic environment that favors the survival of genetically damaged cells.
High level of IGF-1 enhances the risk of prostate, breast and bowel cancer. Many scientists are studying the links between IGF and cancer, but the results are still unclear.
How to Reduce the Chances of Cancer?
Mortality rate increases because of the growth hormone mostly due to cardiovascular events, bone tumors, and bleeding into the brain. It is reported that the risk of death is amplified when higher dosage is injected.
This is the reason why the HCG dose is not recommended without a doctor’s diagnosis. In this case, the benefits are likely to outweigh the risks. If you are interested to know about hormonal can affect your body and what are the signs of hormone deficiency then you can seek an appointment with the endocrinologist to evaluate and discuss the issues.
As outlined in a report from Drugs, the use of Human Chorionic Gonadotropin (HCG) demands meticulous consideration and should be under the guidance of a doctor’s diagnosis. This method ensures that the treatment is tailored to the individual’s specific needs, is deemed suitable for their circumstances, and is overseen by healthcare professionals to enhance safety and effectiveness.
Hormone replacement therapy and cancer:
Different types of HRT may cause cancer:
Breast Cancer:
All types of HRT enhance the risk of cancer but combined HRT has serious effects on the human body. Women using the HRT for more than 10 years are prone to the risk of breast cancer and the chances are more than ten times.
Other Cancer:
HRT with estrogen can increase the risk of womb cancer and possibly ovarian cancer. If a woman continues with HRT for more than 5 years, than risk there is more chance of getting infected by the womb cancer. Combined HRT doesn’t have any effect on any of these cancers and may even reduce the chances of overall cancer risk.
SIMILAR QUESTION
Does Growth Hormone Cause Cancer In Children?
Introduction
Growth hormone (GH) is an important hormone that helps to regulate the growth and development of a child. It is a naturally occurring hormone produced by the pituitary gland located in the brain. While GH is essential for normal growth and development, there are some potential risks associated with its use, including the potential for increased cancer risk. This paper will explore the evidence surrounding the potential link between GH and cancer in children.
Background
GH has been used as a treatment for various medical conditions in children, such as growth hormone deficiencies, Turner syndrome, and Prader-Willi syndrome. It is also used in some cases to treat short stature associated with conditions such as chronic renal failure or cystic fibrosis. The use of GH to treat these conditions has led to increased concerns about the potential for GH to increase the risk of cancer in children.
Evidence
The evidence regarding the potential link between GH and cancer in children is mixed. While there have been a few studies that suggest an increased risk of certain types of cancer in children who have been treated with GH, other studies have found no increased risk.
One study published in the journal Pediatrics looked at the incidence of leukemia in children treated with GH between 1994 and 2002. The study found that the incidence of leukemia was not significantly higher in children treated with GH than in those who were not treated with GH.
Another study, published in the journal Cancer, focused on the risk of solid tumors in children treated with GH. This study found that the incidence of solid tumors was not significantly higher in children treated with GH than in those who were not treated with GH.
Conclusion
The evidence regarding the potential link between GH and cancer in children is mixed. While some studies suggest an increased risk of certain types of cancer in children treated with GH, other studies have found no increased risk. However, more research is needed to better understand the potential risks associated with GH treatment in children.
