Want to know about Human Growth Hormone and what dose of it makes your bone thicker, changes bone structure, strengthens them, or increases its length? We have answered all your queries, but does HGH make bones thicker?
Human growth hormone (HGH) increases bone mass as one of its benefits. Osteoporosis is a medical condition in which bones are extremely prone to be brittle or fractured due to the deficiency of bone mass, especially once an individual reaches age 35,
After this age, bones begin to weaken, and if they continue to live an inactive lifestyle, not consume enough calcium and vitamin D, and lack of sex hormones, which also help strengthen bones.
HGH can do much more to improve bone structure and strength. As you age, the disks between the vertebrae and cartilage may shrink, resulting in you shedding some height.
But with HGH, you would be invigorated. Vigor, per an article on the Health Gain publication, helps you lead an active lifestyle, and hence you are more likely to engage in body flexing.
As you do this, you stretch your muscles and joints. This results in improved posture, which makes you appear taller, leaner, and with heavy bone density, maintaining your height.
HGH is quite beneficial for osteoporotic women who have not had their menstrual periods for at least a year (postmenopausal osteoporosis), as Kerstin Landin-Wilhelmsen et al. could attest.
In 1994-1995, with the approval from the Ethics Committee at Goteborg University, they evaluated 80 women aged 50-70 years with such a problem at the Center for Endocrinology and Metabolism (CEM) at Sahlgrenska University Hospital, Goteborg, Sweden.
Participating in the double-blind trial, the patients and the assisting physicians initially had no idea what kind of treatment would be used.
All of the patients (who were undergoing hormone replacement therapy) received 750 mg calcium and 400 U vitamin D and were randomly given 1.0 U or 2.5 U of recombinant GH or placebo through subcutaneous injections.
The placebo administration eventually stopped after 18 months of the trial, but the GH cohort lasted for 3 years.
Their height, weight, body mass index (BMI), waist and hip sizes, lean mass, handgrip strength, body fat, bone mineral density (BMD), bone mineral content (BMC), and blood pressure were measured, and their blood was taken as samples.
They were also required to undergo bone biopsy and fill in a questionnaire regarding the intensity of their exercise, overall lifestyle, and quality of life.
The researchers discovered that the bone mass of the postmenopausal osteoporotic women increased by 14% thanks to the combination of the highest dose of the recombinant GH (2.5 U), calcium, vitamin D, and HRT, while the lower rGH dose and placebo treatments did not really show the improvement of bone mass.
Here is how HGH helps in making the bones thicker:
HGH acts on bone cells called osteoblasts, which are responsible for bone formation and mineralization.
Osteoblasts produce the organic matrix of bone, which is made up of collagen and other proteins, and also facilitate the deposition of calcium and other minerals to form the hardened bone tissue.
HGH stimulates osteoblasts to produce more bone tissue, leading to an increase in bone thickness and density.
This is achieved through various mechanisms, including the activation of signaling pathways that promote the differentiation and proliferation of osteoblasts. 166739
Bones grow through a combination of osteoblast and osteoclast. Both GH and IGF-1 stimulate these two processes.
HGH also enhances the production of insulin-like growth factor 1 (IGF-1) in the liver, which plays a key role in bone growth and repair. IGF-1 is a peptide hormone that is structurally similar to insulin and exerts similar effects on the body.
It is one of the primary mediators of the bone-building effects of HGH.
IGF-1 stimulates the proliferation of osteoblasts and the production of collagen, a key structural component of bone tissue. Collagen provides the tensile strength of bone, while minerals such as calcium provide its compressive strength.
While osteoblast helps with the formation of new bone tissues and mass, osteoclast dissolves the old and damaged bone tissues, replacing them with new ones and hence increasing bone density and content.
Per an article on the PubMed Advanced User Guide publication, this results in net bone accumulation.
By increasing collagen synthesis, IGF-1 helps to improve bone strength and reduce the risk of fractures.
HGH and IGF-1 also help to reduce bone resorption, the breakdown of bone tissue, by inhibiting the activity of osteoclasts, the cells responsible for bone resorption.
This is achieved through the regulation of signaling pathways that control osteoclast activity and survival.
HGH and IGF-1 also improve calcium absorption and retention, which is important for maintaining bone health. Calcium is a critical mineral for bone strength, and adequate calcium intake is essential for bone growth and remodeling.
HGH and IGF-1 help to promote calcium uptake and retention in bone tissue, which helps to maintain bone density and strength.
Besides, HGH plays a vital role in promoting the growth of cartilage, which is a soft, flexible connective tissue that makes up the structure of the skeleton in the early stages of life.
As children grow, the cartilage gradually hardens and transforms into bone through a process known as ossification.
HGH stimulates the proliferation and differentiation of chondrocytes, the cells responsible for cartilage formation, leading to the growth of new cartilage tissue.
This, in turn, leads to increased bone growth and thickness, especially in the areas that undergo rapid growth during childhood and adolescence, such as the long bones of the arms and legs.
Also, HGH promotes cell division in bone tissue, which can lead to an increase in the number of osteoblasts and other bone cells.
Osteoblasts are bone-forming cells that are responsible for laying down new bone tissue, while osteocytes are mature bone cells that maintain bone structure and integrity.
HGH stimulates the proliferation and differentiation of these cells, leading to an increase in bone density and thickness over time.
An examination was undertaken to assess the effects of HGH on the bone structure of young adults with childhood-onset GH deficiency.
It found that these people registered an increased cortical bone thickness and endosteal expansion after two years.
Per an article on the PubMed Advanced User Guide publication, this culminated in increased bone thickness, preventing late-life bone fragility issues.
In addition, HGH can also stimulate the growth of the periosteum, the outer layer of bone tissue that is rich in blood vessels and nerves. This, in turn, can lead to an increase in bone thickness and strength by promoting the growth of new bone tissue.
SIMILAR QUESTION
Does Hgh Increase Muscle Density?
Introduction
Human growth hormone (HGH) is a naturally occurring hormone in the human body that helps to regulate growth and development. HGH is produced in the pituitary gland and is responsible for the growth of bones and muscles during puberty. Many people are interested in HGH as a means of increasing their muscle density, as well as for increasing their overall physical performance. The purpose of this paper is to explore the effects of HGH on muscle density.
What is HGH?
HGH is a hormone that is produced by the pituitary gland. It is responsible for the growth and development of bones and muscles, and is essential for proper growth during puberty. It is also known to have an anabolic effect on the body, which means it can help to build muscle. HGH is produced in the body at different levels throughout the day, depending on age, sex, and other factors.
Does HGH Increase Muscle Density?
There is no clear evidence that HGH increases muscle density. Some studies have suggested that HGH may increase muscle mass and strength, but these effects are not sustained over time. In addition, studies have not been conducted to determine if HGH increases muscle density.
Studies on HGH and muscle mass
Studies have been conducted to determine the effects of HGH on muscle mass and strength. One study found that participants who used HGH for six months had significantly higher levels of muscle mass and strength than those who did not use HGH. However, these effects did not last beyond the six-month period.
Another study found that HGH did not increase muscle mass or strength in participants. The study concluded that HGH may have some anabolic effects, but it does not increase muscle mass or strength in the long-term.
Conclusion
In conclusion, there is not enough evidence to suggest that HGH increases muscle density. Studies have not been conducted to determine the effects of HGH on muscle density. However, some studies have suggested that HGH may increase muscle mass and strength in the short-term. Ultimately, more research is needed to determine the effects of HGH on muscle density.
