Growth Hormone is a peptide that is single-chained and is secreted by anterior pituitary gland responding to the (GHRF) growth hormone release factor from the hypothalamus. The Growth hormone helps to support protein production in all cells, increases fat mobilization, decreases the use of carbohydrates and promotes the usage of fatty acids meant for energy.
Somatotropin, commonly referred as Human growth hormone or HGH stimulates bone growth and regulates the metabolism of protein, fat and carbohydrate. While HGH is secreted in the body, the scientists in genetic engineering have developed a recombinant growth hormone, which can be used in treating children with stunted growth.
As the name itself implies, Human growth hormone is very important in ascertaining linear growth. Together with thyroid hormones and sex hormones, it plays important role in development and determination of the final height of a person. It has also important role in scheming metabolism of foodstuffs and hence lack of this hormone in children will result in short stature, whereas deficiency in an adult results in depression and weakness.
Effects of Human growth hormone on Human Body:
- Increases calcium retention
- Stimulates cell growth process in each organ of human body
- Decreases degradation of protein
- Fuels the immune system
- Stimulates protein synthesis
- Increases the transport of glucose
- Repairs the injured cells
- Increases metabolism
- Enhances mineralization of bones
- Kindles multiplication and division of chondrocytes of cartilage
- Promotes lipolysis
In a human body, somatotropin or Human growth hormone is at its peak levels in kids and in youth during puberty, thus stimulating the body growth during those ages. The level of secretion of growth hormone declines after puberty, and continues to decline as the person ages.
Recombinant Human growth hormone:
The growth of human body is significantly influenced by the protein hormone somatotropin, a secretion of anterior pituitary gland. The GH hormone which can now be fabricated by genetic engineering technique known as recombinant DNA technology is known as somatropin. The gene associated to growth hormone is incised out of DNA and united into bacterial DNA. These bacteria are then fermented to secrete growth hormone which is alike the one formed in human cells.
Uses and abuses of Human growth hormone:
Growth hormone is clinically used to provide treatment for people distressed from stunted growth problem. Until recombinant HGH became available, the one and only source of GH was pituitary glands. This is extremely costly and hence was used exclusively for the treatment of people with severely restricted growth caused due to severe low secretion of GH. Human growth hormone was also the main cause for Creutzfeldt-Jakob disease.
The treatment using recombinant GH is safer and also easier to obtain and so those people with less severe problems of growth restriction can now be treated. Unfortunately the wider availability of this has been abused.
Sports people are using it to hasten the musculoskeletal injuries healing. It is also used by the body-builders and power sports participants to speed up muscle growth. Few other look-concerned use it to lessen body fat.
However, its excessive use may cause gigantism and acromegaly. Other possible adverse effects include diabetes, arthritis, muscular weakness, heart disorders and impotence.